The sacred building was built in the sixteenth century at the behest of Countess Maria deCardona on the ruins of a pre-existing hospital.

To the munificence of the lady of Avellino was added the one of other nobles of the city, who contributed to the work designed by Father Federico da Montemurro. With three naves, of which the central one is finely frescoed, and with splendid marble altars, the church suffered a sudden collapse in 1726. It was demolished in the Nineteenth century, but after a long debate its reconstruction was decided, which took place in 1933, in gothic style. Inside, there is a beautiful Crucifix and on the altar the painting of the Madonna of Pompei.